Ciliary neurotrophic factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Ciliary neurotrophic factor-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPMT1, ATG12, and CEBPD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPMT1 grouped by Ciliary neurotrophic factor-mediated signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PTPMT1 →	-0.254	-0.152	<.001	.009	3	6
STOMACH	ATG12 →	+0.154	+0.104	.001	.001	3	6
CNS	CEBPD →	-0.234	-0.127	.001	.003	3	4
LUNG_NSCLC_LUAD	GNRHR →	+0.229	+0.127	<.001	.002	3	4
LUNG_NSCLC_LUAD	WARS2 →	+0.145	+0.130	.006	.003	3	4
LUNG_NSCLC_LUAD	PIGV →	-0.201	-0.190	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPMT1 by Ciliary neurotrophic factor-mediated signaling pathway activity — BLOOD_Myeloma

Explore this box plot interactively →