Ciliary neurotrophic factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Ciliary neurotrophic factor-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3AP1, HTR1A, and TBC1D25, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIK3AP1 grouped by Ciliary neurotrophic factor-mediated signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PIK3AP1 →	+0.205	+1.111	<.001	.009	3	3
BREAST	HTR1A →	-0.242	-1.646	.004	.006	3	3
PANCREAS	TBC1D25 →	-0.322	-1.575	.004	.009	3	2
SKIN	ZNF71 →	-0.316	-0.513	.002	.004	3	2
SKIN	PTPRCAP →	-0.265	-0.404	.006	.002	3	2
SKIN	PHKA1 →	+0.167	+0.403	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIK3AP1 by Ciliary neurotrophic factor-mediated signaling pathway activity — OVARY

Explore this box plot interactively →