Ciliary neurotrophic factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Ciliary neurotrophic factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB17, UCHL3, and ALKBH7, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ciliary neurotrophic factor-mediated signaling pathway activity versus ZBTB17 in CNS (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZBTB17 →	+0.524	+0.840	.008	.008	3	3
LUNG_SCLC	UCHL3 →	+1.135	+0.501	<.001	<.001	3	3
LUNG_SCLC	ALKBH7 →	-0.582	-0.354	.005	<.001	3	3
BONE	NUTM2D →	+0.755	+0.347	.004	.008	3	2
OVARY	UNC119 →	-1.165	-1.729	.003	<.001	2	3
OVARY	MATN4 →	-0.146	-1.300	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070120 vs ZBTB17 — CNS

Explore this scatter interactively →