Interleukin-27-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-27-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAS1, OAS2, and IFIH1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-27-mediated signaling pathway activity versus OAS1 in LUNG_NSCLC_LUAD (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OAS1 →	+3.744	+0.225	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	OAS2 →	+3.098	+0.319	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	IFIH1 →	+1.720	+0.316	<.001	<.001	3	15
BLOOD_Lymphoma	STAT1 →	+1.551	+0.170	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	PARP9 →	+1.855	+0.339	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	MX1 →	+3.376	+0.328	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070106 vs OAS1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →