Negative regulation of interleukin-6-mediated signaling pathway

pathway activity — cross-omics
GO:0070104Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-6-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PGRMC1_T74, SAMSN1_S23, and SNX2_S119, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMPGRMC1_T74 →-0.600-0.095.001.00134
LSCCSAMSN1_S23 →+0.754+0.088<.001.00134
GBMSNX2_S119 →-0.388-0.081.003.00534
PDACCOBLL1_S305 →-0.274-0.059<.001<.00134
PDACAHNAK_S2138 →-0.399-0.086.002.00134
PDACFNBP1L_S501 →-0.478-0.080<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration