Proton-transporting two-sector ATPase complex assembly

Across TCGA patient cohorts, RNA activity of the Proton-transporting two-sector ATPase complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERO1A, ZBTB20, and RHEBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proton-transporting two-sector ATPase complex assembly activity versus ERO1A in OV (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ERO1A →	+0.572	+0.094	.001	.005	3	4
UCEC	ZBTB20 →	-0.544	-0.208	.006	<.001	3	4
GBM	RHEBP2 →	+0.331	+0.127	.006	.002	3	4
GBM	TMEM40 →	+0.188	+0.159	.004	<.001	3	4
UCEC	CDKN3 →	+0.610	+0.169	.008	.002	3	3
UCEC	MAN1C1 →	-0.642	-0.181	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070071 vs ERO1A — OV

Explore this scatter interactively →