Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KNOP1, TOP2B, and LRP4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress activity versus KNOP1 in LSCC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KNOP1 →	-0.405	-0.195	<.001	<.001	3	7
LSCC	TOP2B →	-0.657	-0.310	<.001	<.001	3	6
LSCC	LRP4 →	-1.113	-0.230	<.001	<.001	3	6
UCEC	ZNF202 →	-0.276	-0.149	.002	.004	3	6
LSCC	ZNF3 →	-0.527	-0.255	<.001	<.001	3	6
LSCC	SMC3 →	-0.493	-0.187	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070059 vs KNOP1 — LSCC

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