Neuron cellular homeostasis

Across TCGA cell cohorts, RNA activity of the Neuron cellular homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOB, SIAH2, and DCAF5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHOB grouped by Neuron cellular homeostasis-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RHOB →	-2.461	-0.310	<.001	<.001	3	5
OESOPHAGUS	SIAH2 →	-1.065	-0.244	.004	.009	3	5
BREAST	DCAF5 →	-0.541	-0.221	.004	.001	3	5
LARGE_INTESTINE	PRODH →	-1.099	-0.341	.008	.003	3	4
BLOOD_Leukemia	FAM234A →	-0.735	-0.361	.003	<.001	2	5
LIVER	ALDH18A1 →	-1.083	-0.358	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHOB by Neuron cellular homeostasis activity — BONE

Explore this box plot interactively →