Protein-lipid complex assembly

Across TCGA patient cohorts, RNA activity of the Protein-lipid complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGAX, DCAF7, and S100A11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-lipid complex assembly activity versus ITGAX in CCRCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ITGAX →	+0.538	+0.037	.001	.007	3	4
LUAD	DCAF7 →	+0.130	+0.025	.001	.004	3	4
BRCA	S100A11 →	+0.405	+0.026	<.001	.002	3	4
BRCA	C1S →	+0.325	+0.025	.001	.003	3	4
GBM	FLNB →	-0.363	-0.040	.007	.002	3	4
CCRCC	LACTB →	+0.322	+0.040	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0065005 vs ITGAX — CCRCC

Explore this scatter interactively →