Protein localization to postsynapse

Across TCGA cell cohorts, RNA activity of the Protein localization to postsynapse pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN20, CLEC11A, and ZNF286B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLDN20 grouped by Protein localization to postsynapse-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CLDN20 →	-0.190	-0.984	.003	.003	3	4
BREAST	CLEC11A →	-0.824	-0.649	.009	.007	3	4
CNS	ZNF286B →	-0.426	-0.574	.004	.008	3	4
LARGE_INTESTINE	PKIB →	+1.962	+0.794	.001	.004	3	4
BLOOD_Leukemia	MAN2B1 →	-1.234	-0.841	<.001	.007	3	4
BLOOD_Leukemia	CAMK2N1 →	+1.559	+1.227	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLDN20 by Protein localization to postsynapse activity — PANCREAS

Explore this box plot interactively →