Regulation of mitochondrial gene expression

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial gene expression pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX55, ZRANB2, and NUP42, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial gene expression activity versus DDX55 in UVM (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	DDX55 →	+1.562	+0.051	<.001	<.001	3	32
UVM	ZRANB2 →	+2.016	+0.050	<.001	<.001	3	32
UVM	NUP42 →	+1.539	+0.053	<.001	<.001	3	32
UVM	METTL3 →	+1.005	+0.046	<.001	<.001	3	32
UVM	FANCM →	+0.978	+0.054	<.001	<.001	3	32
UVM	METTL4 →	+1.272	+0.055	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062125 vs DDX55 — UVM

Explore this scatter interactively →