Regulation of mitochondrial gene expression

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial gene expression pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPS15_S221, LRBA_S2496, and PHF2_S905, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial gene expression activity versus EPS15_S221 in LSCC (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EPS15_S221 →	-0.342	-0.051	<.001	<.001	3	5
PDAC	LRBA_S2496 →	-0.542	-0.034	<.001	.001	2	6
LSCC	PHF2_S905 →	+0.849	+0.045	<.001	<.001	3	5
LUAD	CSTF3 →	+0.175	+0.031	<.001	.003	3	5
LSCC	CMSS1 →	+0.498	+0.050	.001	<.001	3	5
HNSC	STIM2 →	-0.211	-0.052	.008	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062125 vs EPS15_S221 — LSCC

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