Regulation of mitochondrial gene expression

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial gene expression pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT-ND1, MT-CYB, and GANC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial gene expression activity versus MT-ND1 in COAD (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MT-ND1 →	+0.707	+0.157	<.001	<.001	3	6
COAD	MT-CYB →	+0.876	+0.219	<.001	.001	3	6
COAD	GANC →	-0.367	-0.166	<.001	<.001	3	6
GBM	MT-ND2 →	+0.760	+0.150	.001	.001	3	5
COAD	PPP4R1 →	-0.396	-0.153	<.001	<.001	3	5
BRCA	PHF3 →	-0.457	-0.219	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062125 vs MT-ND1 — COAD

Explore this scatter interactively →