Regulation of mitochondrial gene expression

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial gene expression pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMT10C, MTG2, and FN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRMT10C grouped by Regulation of mitochondrial gene expression-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TRMT10C →	-0.360	-0.399	.002	.001	2	8
OESOPHAGUS	MTG2 →	-0.243	-0.380	.005	<.001	3	4
SOFT_TISSUE	FN1 →	-0.310	-1.018	.001	.001	3	4
LIVER	PHF11 →	-0.375	-1.370	.005	.009	3	3
BONE	WWC2 →	-0.285	-0.553	.002	.006	3	3
LUNG_NSCLC_LUSC	DSP →	+0.375	+0.282	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRMT10C by Regulation of mitochondrial gene expression activity — OESOPHAGUS

Explore this box plot interactively →