Regulation of mitochondrial gene expression

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial gene expression pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XRCC1, CTPS2, and IZUMO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XRCC1 grouped by Regulation of mitochondrial gene expression-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	XRCC1 →	-0.730	-0.262	<.001	<.001	3	5
PANCREAS	CTPS2 →	-0.652	-0.202	.006	.005	3	4
LARGE_INTESTINE	IZUMO1 →	+0.916	+0.239	.002	.003	3	4
LUNG_NSCLC_LUAD	ZNF100 →	-1.423	-0.267	.002	<.001	3	4
STOMACH	ADK →	-1.083	-0.314	.004	.007	3	3
LUNG_SCLC	OSCP1 →	-1.343	-0.313	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XRCC1 by Regulation of mitochondrial gene expression activity — PANCREAS

Explore this box plot interactively →