Zinc ion import into organelle

Across TCGA patient cohorts, RNA activity of the Zinc ion import into organelle pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAT8B, LIPI, and ZNF37BP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Zinc ion import into organelle activity versus NAT8B in LUAD (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NAT8B →	-0.489	-0.925	<.001	<.001	3	4
HNSC	LIPI →	-0.269	-0.597	.007	.002	3	4
HNSC	ZNF37BP →	-0.339	-0.624	.002	.001	3	4
LUAD	CKAP2L →	-0.627	-0.669	<.001	<.001	3	4
LUAD	ZNF271P →	-0.468	-0.969	<.001	<.001	3	4
LUAD	DSG2 →	-0.776	-0.914	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062111 vs NAT8B — LUAD

Explore this scatter interactively →