Positive regulation of programmed necrotic cell death

Across TCGA patient cohorts, RNA activity of the Positive regulation of programmed necrotic cell death pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM37, MANSC1, and SYP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of programmed necrotic cell death activity versus TRIM37 in LSCC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIM37 →	-0.407	-0.248	.001	<.001	3	4
LSCC	MANSC1 →	-0.767	-0.223	<.001	.001	3	3
GBM	SYP →	-1.484	-0.540	<.001	.002	3	3
GBM	RAB3A →	-1.188	-0.474	<.001	.005	3	3
GBM	NEURL1 →	-1.127	-0.551	<.001	<.001	3	3
LSCC	WASF1 →	-1.013	-0.245	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062100 vs TRIM37 — LSCC

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