Stomach development

pathway activity — cross-omics
GO:0062094Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Stomach development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC8A2, TDRKH, and ADH4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMSLC8A2 →-0.748-0.191.006.00534
GBMTDRKH →-0.479-0.199<.001<.00134
CCRCCADH4 →+0.364+0.259.001.00133
CCRCCCHRM3-AS2 →+0.801+0.244.006.00633
LUADYJEFN3 →-0.311-0.271.001.00333
LUADASB16-AS1 →-0.245-0.279.002.00233
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration