Positive regulation of cardiac epithelial to mesenchymal transition

Across TCGA patient cohorts, RNA activity of the Positive regulation of cardiac epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD93, ECM2, and PDGFRB, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cardiac epithelial to mesenchymal transition activity versus CD93 in LAML (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	CD93 →	+1.563	+0.055	<.001	.004	2	33
LGG	ECM2 →	+1.416	+0.071	<.001	<.001	3	30
MESO	PDGFRB →	+1.421	+0.106	<.001	<.001	3	30
SCLC	KCNMB1 →	+1.244	+0.258	<.001	<.001	3	30
UCS	EDNRA →	+1.873	+0.098	<.001	<.001	3	30
THYM	UTRN →	+1.357	+0.080	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062043 vs CD93 — LAML

Explore this scatter interactively →