Positive regulation of cardiac epithelial to mesenchymal transition

Across TCGA cell cohorts, RNA activity of the Positive regulation of cardiac epithelial to mesenchymal transition pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB24, CYP2W1, and CDH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB24 grouped by Positive regulation of cardiac epithelial to mesenchymal transition-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZBTB24 →	-0.102	-0.091	.003	.001	3	5
BLOOD_Lymphoma	CYP2W1 →	-0.412	-1.809	<.001	<.001	3	4
CNS	CDH1 →	-0.150	-0.112	.007	.005	3	4
UPPER_AERODIGESTIVE_TRACT	SLC19A2 →	+0.184	+0.122	<.001	.001	3	4
KIDNEY	ELP1 →	-0.228	-0.186	<.001	.006	3	4
KIDNEY	PKP1 →	-0.296	-0.208	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB24 by Positive regulation of cardiac epithelial to mesenchymal transition activity — CNS

Explore this box plot interactively →