Positive regulation of mitotic sister chromatid segregation

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitotic sister chromatid segregation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATAD2_S342, SMC2, and SMC4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic sister chromatid segregation activity versus ATAD2_S342 in LUAD (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ATAD2_S342 →	+1.390	+0.149	<.001	<.001	3	10
GBM	SMC2 →	+0.630	+0.149	<.001	<.001	3	10
GBM	SMC4 →	+0.613	+0.137	<.001	<.001	3	10
LUAD	ECT2_T359 →	+1.528	+0.140	<.001	<.001	3	10
LSCC	FEN1 →	+0.493	+0.061	<.001	<.001	3	10
LUAD	MCM2 →	+0.640	+0.133	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062033 vs ATAD2_S342 — LUAD

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