Positive regulation of mitotic sister chromatid segregation

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitotic sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA5, PPIHP1, and DDX55, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic sister chromatid segregation activity versus CDCA5 in BRCA (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDCA5 →	+1.060	+0.699	<.001	<.001	3	7
LUAD	PPIHP1 →	+0.421	+0.514	.008	.005	3	7
LSCC	DDX55 →	+0.416	+0.453	.004	.006	3	6
LSCC	INCENP →	+0.573	+0.551	<.001	<.001	3	6
LSCC	ZCCHC8 →	+0.326	+0.438	.002	.001	3	6
LSCC	PUS7 →	+0.558	+0.401	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062033 vs CDCA5 — BRCA

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