Positive regulation of small molecule metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of small molecule metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPF8, QPCT, and TIMELESS_S1173, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of small molecule metabolic process activity versus PRPF8 in GBM (Pearson r = -0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRPF8 →	-0.250	-0.044	<.001	<.001	3	6
GBM	QPCT →	+0.405	+0.027	.001	.007	3	6
GBM	TIMELESS_S1173 →	-0.614	-0.037	<.001	<.001	3	5
GBM	ARVCF_S343 →	-0.532	-0.036	.002	<.001	3	5
BRCA	RSU1 →	+0.329	+0.015	<.001	<.001	3	5
GBM	SF3A1 →	-0.207	-0.028	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062013 vs PRPF8 — GBM

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