Positive regulation of small molecule metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of small molecule metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRB3, ABCA8, and SCARA5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of small molecule metabolic process activity versus MSRB3 in LSCC (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MSRB3 →	+0.766	+0.794	.002	.003	3	5
UCEC	ABCA8 →	+1.374	+0.777	.001	<.001	2	5
HNSC	SCARA5 →	+0.926	+0.712	.009	<.001	3	4
COAD	GFRA2 →	+0.246	+0.690	<.001	<.001	3	4
UCEC	PDE7B →	+0.919	+0.645	.008	.003	2	5
BRCA	NEGR1 →	+0.552	+0.342	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062013 vs MSRB3 — LSCC

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