Positive regulation of small molecule metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of small molecule metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRB, GAPDH, and AASS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPRB grouped by Positive regulation of small molecule metabolic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PTPRB →	+1.275	+0.273	.003	.002	3	5
LIVER	GAPDH →	-1.195	-0.167	<.001	.005	3	4
SKIN	AASS →	+0.840	+0.210	.005	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	VGLL1 →	+4.406	+0.183	.005	.001	3	3
BLOOD_Lymphoma	MDM2 →	-1.137	-0.313	.001	<.001	3	3
LUNG_NSCLC_LUAD	CENPL →	-0.561	-0.118	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPRB by Positive regulation of small molecule metabolic process activity — BLOOD_Lymphoma

Explore this box plot interactively →