Positive regulation of small molecule metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of small molecule metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BLZF1, YIPF2, and MRPS7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of small molecule metabolic process activity versus BLZF1 in BLOOD_Lymphoma (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BLZF1 →	-0.676	-0.127	.007	.001	3	5
BLOOD_Lymphoma	YIPF2 →	-0.686	-0.144	.002	.008	3	5
URINARY_TRACT	MRPS7 →	-0.612	-0.318	.001	.004	3	5
LUNG_NSCLC_LUAD	DIXDC1 →	+0.865	+0.156	.002	.005	3	5
BLOOD_Myeloma	DYRK3 →	+0.978	+0.232	.004	.001	3	4
LUNG_NSCLC_LUAD	SYNE4 →	-1.847	-0.227	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0062013 vs BLZF1 — BLOOD_Lymphoma

Explore this scatter interactively →