Meiosis I cell cycle process

Across TCGA patient cohorts, RNA activity of the Meiosis I cell cycle process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1, RFC1_S368, and RFC1_T506, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiosis I cell cycle process activity versus RFC1 in BRCA (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RFC1 →	+0.349	+0.032	<.001	<.001	3	10
LUAD	RFC1_S368 →	+1.104	+0.089	<.001	<.001	3	10
LUAD	RFC1_T506 →	+1.257	+0.094	<.001	<.001	3	10
HNSC	RFC4 →	+0.627	+0.066	<.001	<.001	3	10
BRCA	RIF1 →	+0.578	+0.050	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.293	+0.080	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061982 vs RFC1 — BRCA

Explore this scatter interactively →