Midbody abscission

Across TCGA patient cohorts, RNA activity of the Midbody abscission pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VPS13C_S737, RPL12_S38, and SEC16A_S314, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midbody abscission activity versus VPS13C_S737 in LUAD (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	VPS13C_S737 →	-0.474	-0.045	.001	.004	3	7
LUAD	RPL12_S38 →	+0.758	+0.053	<.001	<.001	3	6
LUAD	SEC16A_S314 →	+0.617	+0.039	<.001	.006	3	6
LUAD	MELK_S336 →	+1.483	+0.091	<.001	<.001	3	6
LUAD	EDC3_S131 →	+0.482	+0.058	<.001	<.001	3	5
LUAD	TOP2A_S1213 →	+0.545	+0.051	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061952 vs VPS13C_S737 — LUAD

Explore this scatter interactively →