Establishment of protein localization to plasma membrane

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNTB2_S222, RPL5, and RPL10A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to plasma membrane activity versus SNTB2_S222 in GBM (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNTB2_S222 →	+1.026	+0.047	<.001	<.001	3	8
LUAD	RPL5 →	-0.155	-0.022	<.001	.001	3	7
LUAD	RPL10A →	-0.178	-0.025	<.001	<.001	3	7
GBM	RRM2 →	-0.829	-0.058	<.001	<.001	3	7
BRCA	SRPK1 →	-0.320	-0.030	<.001	<.001	3	7
UCEC	TNS2_S102 →	+0.656	+0.053	.002	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061951 vs SNTB2_S222 — GBM

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