Establishment of protein localization to plasma membrane

Across TCGA patient cohorts, RNA activity of the Establishment of protein localization to plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANK3_S1459, PLEKHO2, and ADCY6_S576, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to plasma membrane activity versus ANK3_S1459 in LUAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ANK3_S1459 →	+0.907	+0.235	<.001	<.001	2	5
UCEC	PLEKHO2 →	-0.307	-0.265	.003	<.001	3	4
LUAD	ADCY6_S576 →	+0.427	+0.232	<.001	<.001	3	4
LUAD	AFDN_S1799 →	+1.067	+0.296	<.001	<.001	3	4
LSCC	AFDN_S557 →	+0.991	+0.290	<.001	<.001	3	4
PDAC	SCRIB_S1486 →	+0.546	+0.201	.001	.002	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061951 vs ANK3_S1459 — LUAD

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