Establishment of protein localization to plasma membrane

Across TCGA cell cohorts, RNA activity of the Establishment of protein localization to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABRACL, HSD17B13, and MAPK11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABRACL grouped by Establishment of protein localization to plasma membrane-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ABRACL →	+1.575	+0.857	.006	.002	3	3
CNS	HSD17B13 →	-0.185	-0.528	.008	.007	3	3
KIDNEY	MAPK11 →	-1.355	-1.233	.002	.007	3	3
KIDNEY	CFD →	-2.138	-0.987	<.001	.008	3	3
STOMACH	UTP18 →	-0.365	-0.211	.007	<.001	3	3
STOMACH	C18orf21 →	-0.646	-0.267	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABRACL by Establishment of protein localization to plasma membrane activity — BLOOD_Leukemia

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