Establishment of protein localization to plasma membrane

Across TCGA cell cohorts, RNA activity of the Establishment of protein localization to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMD4A, AAMDC, and INSIG2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of protein localization to plasma membrane activity versus SAMD4A in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SAMD4A →	+1.935	+0.201	<.001	.003	3	5
LIVER	AAMDC →	+1.223	+0.134	.009	.004	2	6
LARGE_INTESTINE	INSIG2 →	+0.750	+0.131	.003	.005	3	5
LUNG_NSCLC_LUAD	CNGA1 →	+0.652	+0.159	.002	<.001	3	4
PANCREAS	TMEM62 →	+0.906	+0.150	.003	.003	3	4
PANCREAS	STPG2 →	+0.085	+0.178	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061951 vs SAMD4A — PANCREAS

Explore this scatter interactively →