Regulation of protein K48-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Regulation of protein K48-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF9, RNU6-1046P, and C19orf84, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein K48-linked ubiquitination activity versus TNFSF9 in LSCC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNFSF9 →	+0.746	+0.173	.004	.002	3	3
LSCC	RNU6-1046P →	-0.408	-0.142	.003	.001	3	3
LSCC	C19orf84 →	+0.134	+0.100	<.001	.009	3	3
UCEC	EPB41L4A →	-0.713	-0.167	<.001	<.001	3	3
UCEC	VN1R51P →	+0.403	+0.145	.004	.002	3	3
PDAC	PCDHB6 →	-0.267	-0.214	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061945 vs TNFSF9 — LSCC

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