Regulation of astrocyte activation

Across TCGA patient cohorts, RNA activity of the Regulation of astrocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK3, C2CD5, and RABGAP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of astrocyte activation activity versus MAPK3 in CCRCC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MAPK3 →	+0.391	+0.219	.009	.001	3	3
GBM	C2CD5 →	+0.242	+0.185	.001	.006	3	3
GBM	RABGAP1 →	+0.383	+0.278	.001	.007	3	3
GBM	MAL →	+1.209	+0.242	.005	.003	3	3
GBM	KIAA2026 →	+0.568	+0.319	<.001	<.001	3	3
GBM	H3P43 →	+1.015	+0.241	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061888 vs MAPK3 — CCRCC

Explore this scatter interactively →