Microtubule organizing center localization

Across TCGA patient cohorts, RNA activity of the Microtubule organizing center localization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC00598, PPP1R32, and PPM1K, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule organizing center localization activity versus LINC00598 in LSCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LINC00598 →	-0.181	-0.399	<.001	.007	3	4
BRCA	PPP1R32 →	-0.416	-0.634	.008	.005	3	4
HNSC	PPM1K →	-0.975	-0.723	<.001	<.001	3	4
HNSC	CD28 →	-0.653	-0.456	<.001	<.001	3	4
HNSC	MAGI2-AS3 →	-0.435	-0.373	.003	.006	3	4
BRCA	FZD4 →	-0.782	-0.538	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061842 vs LINC00598 — LSCC

Explore this scatter interactively →