Golgi lumen acidification

Across TCGA patient cohorts, RNA activity of the Golgi lumen acidification pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2S, ACOT7, and ADAM33, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi lumen acidification activity versus UBE2S in LSCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBE2S →	+0.529	+0.225	.003	.002	3	4
PDAC	ACOT7 →	+0.791	+0.218	<.001	<.001	3	4
BRCA	ADAM33 →	-0.791	-0.110	.002	.001	3	3
BRCA	NSA2P3 →	-0.486	-0.122	.002	.002	3	3
LSCC	RAB5IF →	+0.499	+0.158	.005	.002	3	3
LSCC	FCER2 →	-0.491	-0.141	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061795 vs UBE2S — LSCC

Explore this scatter interactively →