CAMKK-AMPK signaling cascade

Across TCGA patient cohorts, RNA activity of the CAMKK-AMPK signaling cascade pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID2, SERPINA5, and SULF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CAMKK-AMPK signaling cascade activity versus NID2 in CCRCC (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NID2 →	+0.447	+0.070	<.001	<.001	3	8
LSCC	SERPINA5 →	+0.594	+0.095	<.001	.001	3	7
OV	SULF1 →	+0.843	+0.044	.005	.003	3	7
GBM	COL1A1 →	+0.801	+0.063	.003	.001	3	7
GBM	COL1A2 →	+0.709	+0.060	.005	.002	3	7
COAD	ITIH1 →	+0.663	+0.046	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061762 vs NID2 — CCRCC

Explore this scatter interactively →