Leukocyte adhesion to arterial endothelial cell

pathway activity — cross-omics
GO:0061757Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Leukocyte adhesion to arterial endothelial cell pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFTPA2, ZNF233, and POPDC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCSFTPA2 →+0.361+0.610.005.00434
GBMZNF233 →-0.713-1.113<.001<.00134
CCRCCPOPDC2 →-0.520-0.662.005.00133
CCRCCFILIP1L →-0.892-1.001<.001.00733
CCRCCMIR5190 →-1.065-1.025.001.00333
UCECFABP3 →-0.649-1.052<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration