Leukocyte adhesion to vascular endothelial cell

Across TCGA patient cohorts, RNA activity of the Leukocyte adhesion to vascular endothelial cell pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCSD1, MYO1F, and C1orf162, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte adhesion to vascular endothelial cell activity versus RCSD1 in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.726	+0.252	<.001	<.001	3	10
OV	MYO1F →	+0.790	+0.210	<.001	<.001	3	9
OV	C1orf162 →	+0.744	+0.182	<.001	<.001	3	9
GBM	TMEM273 →	+0.669	+0.172	<.001	<.001	3	9
OV	LCP2 →	+0.939	+0.194	<.001	<.001	3	9
GBM	FGD2 →	+0.815	+0.227	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061756 vs RCSD1 — GBM

Explore this scatter interactively →