Leukocyte adhesion to vascular endothelial cell

Across TCGA cell cohorts, RNA activity of the Leukocyte adhesion to vascular endothelial cell pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAMLD1, IQANK1, and EMP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAMLD1 grouped by Leukocyte adhesion to vascular endothelial cell-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MAMLD1 →	-2.253	-2.108	.001	.001	3	5
URINARY_TRACT	IQANK1 →	+4.234	+1.649	<.001	.001	3	5
LUNG_SCLC	EMP3 →	-3.460	-1.232	.001	<.001	3	5
LUNG_SCLC	RHOC →	-2.310	-1.066	.002	.003	3	5
LUNG_SCLC	ZYX →	-3.015	-1.185	.002	.003	3	5
LUNG_SCLC	RIN1 →	-2.159	-1.112	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAMLD1 by Leukocyte adhesion to vascular endothelial cell activity — URINARY_TRACT

Explore this box plot interactively →