Motor behavior

Across TCGA patient cohorts, RNA activity of the Motor behavior pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC4, RPL7L1, and SMC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motor behavior activity versus RFC4 in LSCC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC4 →	-0.419	-0.054	<.001	<.001	3	6
LSCC	RPL7L1 →	-0.343	-0.044	.002	.006	3	6
LSCC	SMC2 →	-0.483	-0.058	<.001	<.001	3	6
LSCC	FANCI →	-0.526	-0.052	.001	<.001	3	6
UCEC	VIM →	+0.490	+0.073	.002	.001	3	6
BRCA	CNRIP1 →	+0.432	+0.034	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061744 vs RFC4 — LSCC

Explore this scatter interactively →