Motor learning

pathway activity — cross-omics
GO:0061743Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Motor learning pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR4308, UEVLD, and TMEM9B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCMIR4308 →-0.563-0.621.003<.00133
GBMUEVLD →+0.326+0.291.001.00233
LSCCTMEM9B →+0.429+0.689<.001<.00133
BRCAPKN3 →-0.733-0.563<.001.00333
OVLEPR →+0.614+0.860.009<.00133
LSCCPTP4A3 →-0.491-0.778<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration