Lipophagy

Across TCGA patient cohorts, RNA activity of the Lipophagy pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALM, RNA5SP168, and F5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipophagy activity versus GALM in LSCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GALM →	+0.402	+0.210	.002	<.001	3	3
BRCA	RNA5SP168 →	-0.293	-0.225	.001	.003	3	3
HNSC	F5 →	+0.545	+0.199	.004	.009	3	3
OV	B4GALT4 →	+0.385	+0.083	.001	.009	3	3
OV	TMEM229B →	+0.408	+0.089	.005	.004	3	3
OV	IL4R →	+0.799	+0.109	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061724 vs GALM — LSCC

Explore this scatter interactively →