Lipophagy

Across TCGA cell cohorts, RNA activity of the Lipophagy pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA4, EEF1E1, and TRAIP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGA4 grouped by Lipophagy-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ITGA4 →	-1.897	-0.899	.002	.006	3	4
OVARY	EEF1E1 →	+0.800	+0.923	.002	.005	3	3
OVARY	TRAIP →	-0.773	-1.229	.003	.003	3	3
LARGE_INTESTINE	TMEM54 →	+1.878	+1.410	<.001	.005	3	3
CNS	TKFC →	+0.754	+1.216	.004	.004	3	3
BONE	TNFSF9 →	-1.255	-1.487	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGA4 by Lipophagy activity — LUNG_SCLC

Explore this box plot interactively →