Detoxification of inorganic compound

Across TCGA cell cohorts, RNA activity of the Detoxification of inorganic compound pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAT, IFT43, and TOPBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification of inorganic compound activity versus CAT in BLOOD_Leukemia (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CAT →	+1.407	+0.203	<.001	<.001	3	8
SOFT_TISSUE	IFT43 →	-1.166	-0.262	<.001	.004	3	5
LIVER	TOPBP1 →	+0.852	+0.352	.002	.003	3	5
LARGE_INTESTINE	OPTN →	-1.688	-0.224	.001	.001	3	5
LARGE_INTESTINE	ELFN2 →	-1.894	-0.243	<.001	<.001	3	5
LARGE_INTESTINE	FSTL3 →	-1.876	-0.188	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061687 vs CAT — BLOOD_Leukemia

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