Chaperone-mediated autophagy

Across TCGA patient cohorts, RNA activity of the Chaperone-mediated autophagy pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNRPD2, C1QB, and CLASRP_S547, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chaperone-mediated autophagy activity versus SNRPD2 in GBM (Pearson r = -0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRPD2 →	-0.243	-0.054	<.001	<.001	3	6
COAD	C1QB →	+0.515	+0.048	.002	.003	3	6
GBM	CLASRP_S547 →	-0.288	-0.058	<.001	<.001	3	6
GBM	PHF14 →	-0.243	-0.062	<.001	<.001	3	6
LSCC	RPL11 →	-0.100	-0.050	.003	.003	3	5
BRCA	RPRD2_S928 →	-0.619	-0.058	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061684 vs SNRPD2 — GBM

Explore this scatter interactively →