Chaperone-mediated autophagy

Across TCGA patient cohorts, RNA activity of the Chaperone-mediated autophagy pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENTR1, SPDL1, and DNAJB11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chaperone-mediated autophagy activity versus ENTR1 in GBM (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ENTR1 →	-0.251	-0.194	<.001	<.001	3	5
UCEC	SPDL1 →	-0.619	-0.116	.003	.009	3	4
UCEC	DNAJB11 →	-0.423	-0.123	<.001	.003	3	4
OV	TRIP4 →	-0.391	-0.160	.001	.004	3	4
GBM	CSTF1 →	-0.260	-0.224	<.001	<.001	3	4
GBM	UBA2 →	-0.319	-0.201	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061684 vs ENTR1 — GBM

Explore this scatter interactively →