Chaperone-mediated autophagy

Across TCGA cell cohorts, RNA activity of the Chaperone-mediated autophagy pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCTS1, LAMP2, and PSMD10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chaperone-mediated autophagy activity versus MCTS1 in LIVER (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MCTS1 →	+1.255	+0.247	.008	<.001	3	5
LIVER	LAMP2 →	+1.981	+0.192	.005	<.001	2	6
OVARY	PSMD10 →	+0.710	+0.212	<.001	.004	3	5
LUNG_NSCLC_LUAD	VASN →	+1.628	+0.133	.001	.004	3	5
LUNG_NSCLC_LUAD	ATP6AP1 →	+0.617	+0.118	.002	<.001	3	5
BONE	ATG4A →	+0.944	+0.135	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061684 vs MCTS1 — LIVER

Explore this scatter interactively →