Cytoskeleton-dependent cytokinesis

Across TCGA patient cohorts, RNA activity of the Cytoskeleton-dependent cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AZGP1, IQCJ-SCHIP1-AS1, and IFNA8, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoskeleton-dependent cytokinesis activity versus AZGP1 in BRCA (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AZGP1 →	-2.865	-0.213	.002	.008	3	2
BRCA	IQCJ-SCHIP1-AS1 →	+0.240	+0.245	.003	.001	3	2
OV	IFNA8 →	-0.154	-0.266	.007	.005	3	1
OV	CEP89 →	-0.567	-0.220	.009	.003	3	1
OV	KCNA10 →	-0.062	-0.266	.007	.005	3	1
OV	MALL →	+0.932	+0.282	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061640 vs AZGP1 — BRCA

Explore this scatter interactively →