Regulation of protein complex stability

Across TCGA patient cohorts, RNA activity of the Regulation of protein complex stability pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HINT1, LINC02289, and GSR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein complex stability activity versus HINT1 in CCRCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HINT1 →	+0.385	+0.665	.001	.001	3	4
UCEC	LINC02289 →	-0.304	-0.382	.006	.007	3	4
CCRCC	GSR →	+0.361	+0.840	.001	<.001	3	3
BRCA	CDK8 →	-0.501	-0.201	<.001	<.001	3	3
CCRCC	RNU5D-1 →	-0.627	-0.460	.003	.007	3	3
GBM	RASSF2 →	-0.658	-0.607	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061635 vs HINT1 — CCRCC

Explore this scatter interactively →